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A decade of change - lessons learned from prenatal diagnostics in Central Denmark region in 2008-2018

Dorte Launholt Lildballe; Naja Becher; Else Marie Vestergaard; Rikke Christensen; Stina Lou; Puk Sandager; Lars Henning Pedersen; Kasper Gadsbøll; Olav Bjørn Petersen; Ida Vogel

Introduction

In 2011, it was decided to implement chromosomal microarray in prenatal testing in the Central Denmark Region, mainly due to the expected higher diagnostic yield. Chromosomal microarray was introduced gradually for an increasing number of pregnancies and without a transition period where both karyotyping and chromosomal microarray were performed: first malformations (2011), then large nuchal translucency (2013), then high risk at combined first trimester risk screening (2016) and finally for all indications (2018). This retrospective study summarizes 11 years of using chromosomal microarray in invasive prenatal testing and presents the effect on diagnostic yield and turnaround time. Furthermore, the concerns when introducing chromosomal microarray are presented and discussed.

A decade of change - lessons learned from prenatal diagnostics in Central Denmark region in 2008-2018

Udgivelsesform Videnskabelige artikler
År 2023
Udgiver Acta Obstetricia et Gynecologica Scandinavica

Forfattere

Stina Lou